FGF23 Predicts Development of CKD Anemia

Turbulent serum fibroblast enlargement factor 23 (FGF23) are associated with an ennobled risk of anemia in patients with staunch kidney malady (CKD) but not on dialysis, agreeing to investigate findings justified nowed at the 54th European Renal Association-European Dialysis and Relocate Linking congress in Copenhagen, Denmark.

In a ineluctable longitudinal rote that encompassed 2089 sufferers with non-dialysis CKD, anemia happened in 16.5%, 21.6%, 31.3%, and 32% of patients in the 1st, 2nd, 3rd, and 4th quartile of serum FGF23, severally, Sangmi Lee, MD, and joins at Yonsei University in Seoul, South Korea, divulged.

In a fully natural multivariable evaluation, patients in the 3rd and 4th quartiles of FGF23 had a suggestive 66% and 84% spread imperil of anemia be in a classed with patients in the 1st quartile.

“Our sentences suggest that serum FGF23 may be an individual predictor of anemia,” the conspirators concluded in their weigh abridge.

The work contingent had a have the persuasiveness age of 53.6 years and 1275 (61%) were men.  The median helping was 21 months. At baseline, 925 cases (44.3%) had anemia, which the investigators delineated as a hemoglobin accordant less than 13 g/dL in men and teeny than 12 g/dL in concubines. Of the 1164 patients without anemia at baseline, anemia resulted in 295 (25.3%).

Recommendation

Lee S, Joo YS, Kang SW. Ciruclating fibroblast tumour factor-23 demolishes are associated with an bourgeoned imperil of anemia flourishing in patients with non-dialysis inveterate kidney sickness. Data backsheeshed at the 54th European Renal Association-European Dialysis and Switch Association congress in Copenhagen, Denmark, May 24–27. Cut SP332.

Values of hyperkalemia associated with articulation of renin-angiotensin-aldosterone methodology inhibitors change by age and comorbidities.

Longitudinal fantasize over with preplanned serum potassium ascertainments may accommodate a uncountable unerring think of the tax of hyperkalemia stock CKD patients.

Long-sufferings in the squiffiest quintile of urinary albumin excretion had a 4.5-fold extended risk of urothelial cubicle carcinoma vs those in quintiles 1-3.

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