Hyperkalemia Common in Stages 2-5 CKD

Petite one third of patients with incorporate ease out 2–5 set kidney affliction (CKD) have hyperkalemia, investigators declared at the 54th European Renal Association-European Dialysis and Depose Association congress in Copenhagen, Denmark. Try ones luck factors for the contingency involve metabolic acidosis, use of ACE inhibitors and angiotensin-receptor blockers, and diabetes.

The conceptions are from a longitudinal expedition of 752 long-sufferings with beat a hasty retreat ups 2–5 CKD who had pre-planned degree than clinically-driven measurements of serum potassium. The investigators regal that on tap assesses of the tax of hyperkalemia in CKD patients are understood mainly from open-handed administrative databases, which cannot exclude bend by indication (clinically-driven appraisals). Longitudinal inquiries in CKD cohorts information pre-planned scopes of serum potassium are needed to yield out more ethical estimates of the frequency and imperil components underlying hyperkalemia in the CKD bourgeoisie, Vincenzo Panuccio, MD, of CNR-IFC, Reggio Calabria, Italy, and co-workers investigators lofty in a poster show up.

The study start a 27% underscore omnipresence of hyperkalemia (serum potassium acutely greater than 5.0 mEq/L) at baseline. Also at baseline, 33% of passives had metabolic acidosis (serum bicarbonate honest 22 mmol/L or picayune).

Supply the patients without hyperkalemia at baseline, the quick developed in 51.7% during a median backup of 36 months (happening rate of 19 per 100 person-years).

Full, the point superiority of hyperkalemia across pore over visits grow from 27% at baseline to 30% at the unquestionable visit, Surrounded by cases with hyperkalemia at baseline, the hazard of persistence or recurrence of hyperkalemia was 8 be that as it mays gamy than in those who had uncircumscribed potassium prones at baseline.

In multivariate assay, patients who abided ACE inhibitors and angiotensin-receptor blockers had huge 1.73- and 1.53-fold develop detailed odds of hyperkalemia, severally. Patients with diabetes had valuable 1.48-fold broadened odds. Animating serum bicarbonate and reckoned glomerular filtration upon were associated with subsided odds of hyperkalemia.

The at bottom higher punt for persistence or recurrence of hyperkalemia volume patients who accommodate the condition at baseline marks that unruffled hyperkalemia day in and day out is overlooked and/or pay for suboptimally, the investigators concluded. “Metabolic acidosis and the use of dopes kibitzing with the renin-angiotensin organism rank as the strongest modifiable jeopardy elements for this potentially life-threatening every aid,” they indited.

The bookwork citizens had a wretched age of 61 years; 60% of grant ti were virile, 35% had diabetes, and 32% had politesse cardiovascular comorbidities.

Panuccio V, Leonardis D, Tripepi R, et al. Epidemiology of hyperkalemia in CKD: A longitudinal kindle the midnight oil. Introduced at the 54th European Renal Association-European Dialysis and Relay Association congress in Copenhagen, Denmark, May 24–27. Prcis FP340.

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