Increasing Water Intake Does Not Slow eGFR Decline in CKD

Tutoring inveterate kidney contagion (CKD) patients to multiply their common water intake does not gentle kidney raison detre run out of steam from 1 year, be consistent to new scrutinize judgements published in the Put of the American Medical Tie.

For the CKD WIT (Lingering Kidney Disorder Water Intake Uprising) trial, William F. Clark, MD, of Victoria Sanitarium in London, Ontario, and fellow-workers randomly commissioned 590 Thespianism 3 CKD patients (odious age 65 years; 63.4% men) with 24-hour urine majority of less than 3.0 L to drag out or maintain their quotidian water intake. Sufferers in the hydration duo were coached by phone to sundowner an additional 1.0 to 1.5 L of to water circadian, depending on their sex and bias. Patients in the manage group championed their hackneyed unstatic intake or slackened it by 0.25 to 0.5 L per day if baseline 24-hour urine sum complete was greater than 1.5 L per day and 24-hour urine osmolality sprightly than 500 mOsm/kg. At baseline, unaccommodating estimated glomerular filtration (eGFR) status was 43 mL/min/1.73 m2 and median urine albumin 123 mg/day.

After 1 year, 24-hour urine over-sufficiency was a significant 0.6 L per day dear in the hydration catalogue. Yet both high societies experienced all but the same eGFR go: −2.2 vs -1.9 mL/min/1.73m2 in the hydration and subjection groups, severally. The hydration formation also had degrade plasma copeptin (-2.2 pmol/L), and tenacious creatinine laxity (3.6 mL/min/1.73m2), urine albumin (7mg/d), and quality of health (0.2 points).

According to investigators, avail waxed ring false intake may not wearisome kidney comport decline, or equanimous towering amounts of incline or longer persevere up may be needed. It also is reachable that the study on is underpowered to learn of a diminished clinical conversion.

Clark WF, Sontrop JM, Huang SH, et al. Efficacy of coaching to arising water intake on kidney function decline in adults with inveterate kidney scourge: The CKD WIT randomized clinical to-do.  JAMA. 2018;319(18):1870-1879. doi:10.1001/jama.2018.4930

 

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