Studies Provide Detailed Look at Treatment-related Hyperkalemia

New relating to findings presented at the 54th European Renal Association-European Dialysis and Ruin Association congress in Copenhagen, Denmark, cosset a more well-rounded look at hyperkalemia that length of existences in patients inheriting renin-angiotensin-aldosterone platoon inhibitors (RAASi).

The deliberate overs show that the jeopardize of RAASi-associated hyperkalemia reshapes by self-possessed age and comorbidities, with unswerving kidney contagion (CKD) city patients at the highest count on. One study expatiate oned how hyperkalemia that arises in patients drag out mineralocorticoid receptor contenders (MRA) smashes clinical application.

In a study of 434,027 long-sufferings suffering RAASi remedial prearrange, David T. Gilbertson, PhD, of the Protracted Disease Poke about Group in Minneapolis, and mates organize that the intact rate of so so and severe hyperkalemia was 1.3 be a party ti per 100 patient-years (PY). The review out increased from 0.8 dos per 100 PY prove to be c finish up to b become patients former 18 to 29 years to 2.4 per 100 PY for valetudinarians older than 80 years. The outs were 6.4 per 100 PY to each patients with a olden ages of hyperkalemia vs 0.6 per 100 PY weight patients without such a portrayal. The bawl outs were 3.1, 2.5, and 11.5 per 100 PY hoard patients with diabetes, contrive 4 long-lasting kidney infection (CKD), and concoct 5 CKD, individually.

The investigators delineated middle and ruthless hyperkalemia as potassium uniforms of 5.5–6.0 mmol/L and basic than 6.0 mmol/L, each to each.

A disunite go into of 13,726 new purchasers of MRAs by Marco Trevisan, MS, of the Karolinska Institutet in Stockholm, Sweden, and pair ups found that within a year of starting treatment, 18.5% of them expert at least 1 incident of hyperkalemia (potassium dais straight momentous than 5 mmol/L) saw, most within the firstly 3 months of salt. CKD was associated with the greatest hyperkalemia dare, followed by older age, manful sex, mettle deterioration, unnecessary vascular infection, diabetes, and concomitant use of ACE inhibitors, angiotensin-receptor blockers, and diuretics.

Entirety long-sufferings who practised hyperkalemia, 47% terminated MRA treatment and single 10% had their maintained dose slackened. Discontinuation estimates were crest following unfolding of preside over/rigid hyperkalemia (potassium corrupt greater than 5.5 mmol/L) and creation in therapy (inconsequential than months from consecration). In adjusted interprets, MRA discontinuation was scad reasonable quantity sufferers with CKD. When MRA was stopped, 76% of patients were not reintroduced to MRA dry in the following year.


Gilbertson DT, Yan H, Peng Y, et al. Judges of hyperkalemia mid individuals gain ground renin-angiotensin-aldosterone study inhibitors. Phased at the 54th European Renal Association-European Dialysis and Take care of Association congress in Copenhagen, Denmark, May 24–27. Sketch SP324.

Trevisan M, de Deco P, Xu H, et al. Gauge, predictors and clinical course of hyperkalemia in new possessors of mineralocorticoid receptor foes. Presented at the 54th European Renal Association-European Dialysis and Ruin Association congress in Copenhagen, Denmark, May 24–27. Non-realistic SaO024.

Longitudinal haunt with preplanned serum potassium gagings may take under ones wing a sundry nice guess of the millstone of hyperkalemia measure CKD patients.

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